Breakthrough bacteremia by linezolid-susceptible Enterococcus faecalis under linezolid treatment in a severe polytrauma patient.
نویسندگان
چکیده
Fabio Arena, Tommaso Giani, Angelo Galano, Marcello Pasculli, Valeria Peccianti, Maria Iris Cassetta, Andrea Novelli, Gian Maria Rossolini Department of Medical Biotechnologies, University of Siena, Siena, Italy; Surgical Intensive Care Unit, Siena University Hospital, Siena, Italy; Department of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Florence, Florence, Italy; Department of Experimental and Clinical Medicine, Section of Critical Care and Specialistic Medicines, University of Florence, Florence, Italy; Clinical Microbiology and Virology Unit, Department of Laboratory Medicine, Careggi University Hospital, Florence, Italy
منابع مشابه
Reply to "Breakthrough bacteremia by linezolid-susceptible Enterococcus faecalis under linezolid treatment in a severe polytrauma patient".
Arena et al. describe in this issue a case of a young patient admitted to the intensive care unit for an acute subdural hematoma who developed bacteremia due to Enterococcus faecalis under linezolid treatment (1). They measured linezolid concentrations after 6 h of the last administration on 2 occasions, and both were close (2.13 mg/liter) or below (1.47 mg/liter) the MIC of E. faecalis (2 mg/l...
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Resistance to linezolid is rare in clinical isolates of Enterococcus faecalis. A strain resistant to this antimicrobial but susceptible to vancomycin was found to cause central venous catheter colonization in a patient who never received linezolid.
متن کاملPrevalence and detection of mixed-population enterococcal bacteremia.
Mixed-population (heterogeneous) enterococcal bacteremia (MEB) is rarely reported. Based on one occasion in which Vitek2 missed a vancomycin-resistant subpopulation isolated from a patient, we developed a simple method to detect this subpopulation and determined MEB frequency. The four patients presented here had either Enterococcus faecium or Enterococcus faecalis bacteremia caused by both van...
متن کاملIntrathecal/Intraventricular Linezolid in Multidrug-Resistant Enterococcus faecalis Ventriculitis
Background The use of intrathecal antibiotic therapy for the treatment of ventriculitis and/or meningitis has demonstrated efficacy especially when sterilization of the cerebrospinal fluid is not possible with intravenous antibiotics alone. Case Description We describe the successful treatment of Enterococcus faecalis ventriculitis utilizing intrathecal linezolid in a 32-year-old female patient...
متن کاملComparative in vitro activities and postantibiotic effects of the oxazolidinone compounds eperezolid (PNU-100592) and linezolid (PNU-100766) versus vancomycin against Staphylococcus aureus, coagulase-negative staphylococci, Enterococcus faecalis, and Enterococcus faecium.
The activities of the oxazolidinone antibacterial agents eperezolid (PNU-100592) and linezolid (PNU-100766) were compared with that of vancomycin against clinical isolates of methicillin-susceptible and -resistant Staphylococcus aureus (n = 200), coagulase-negative staphylococci (n = 100), and vancomycin-susceptible and -resistant Enterococcus faecalis and Enterococcus faecium (n = 50). Eperezo...
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عنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 57 12 شماره
صفحات -
تاریخ انتشار 2013